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Chemical Structure : CB34
Catalog No.: PC-60733Not For Human Use, Lab Use Only.
A potent, selective translocator protein 18 kDa (TSPO/PBR) agonist with IC50 of 2.59 and 1.03 nM in competing with [3H]-PK11195 for binding to membrane preparations from rat cerebral cortex and ovary, respectively.
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A potent, selective translocator protein 18 kDa (TSPO/PBR) agonist with IC50 of 2.59 and 1.03 nM in competing with [3H]-PK11195 for binding to membrane preparations from rat cerebral cortex and ovary, respectively; does not show any affinity for central benzodiazepine receptors, has little or no marked effects on GABA-evoked Cl- currents; induces a dose-dependent increase in the concentrations of neuroactive steroids in plasma and brain, stimulate brain steroidogenesis in vivo.
| M.Wt | 438.777 | |
| Formula | C21H22Cl3N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Serra M, et al. Br J Pharmacol. 1999 May;127(1):177-87.
2. Mitsui K, et al. Neuropharmacology. 2015 Dec;99:51-66.
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