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Chemical Structure : CC-671
CAS No.: 1618658-88-0
Catalog No.: PC-61022Not For Human Use, Lab Use Only.
CC-671 (CC671) is a potent, selective, dual TTK (Mps1)/CLK2 inhibitor with IC50 of 5/3 nM, respectively.
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|---|---|---|---|
| 10 mg | $258 | In stock | |
| 25 mg | $458 | In stock | |
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| 200 mg | Get quote | ||
| 1 g | Get quote |
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CC-671 (CC671) is a potent, selective, dual TTK (Mps1)/CLK2 inhibitor with IC50 of 5/3 nM, respectively.
CC-671 weakly inhibits DYRK3, DYRK1A, PHKG, DYRK1B, and CLK1 with IC50 of 0.1-0.3 uM, and displays excellent kinase selectivity (7/235 kinases > 80% inhibition at 3 uM).
CC-671 inhibits autophosphorylation of TTK at T686 or phosphorylation of SR protein 75 with IC50 of 0.057 and 0.549 uM in Cal-51 cells.
CC-671 demonstrates strong single agent in vivo efficacy in multiple TNBC xenograft models without significant body weight loss.
| M.Wt | 512.57 | |
| Formula | C28H28N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7H-pyrrolo-[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-N-methylbenzamide |
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1. Riggs JR, et al. J Med Chem. 2017 Nov 9;60(21):8989-9002.
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