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Chemical Structure : CDDO Methyl ester
CAS No.: 218600-53-4
Catalog No.: PC-43494Not For Human Use, Lab Use Only.
CDDO Methyl ester (NSC 713200, RTA 402, Bardoxolone methyl, CDDO-Me) is a potent activator of Nrf2, inhibits proliferation, induces differentiation and apoptosis in AML cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $78 | In stock | |
| 50 mg | $118 | In stock | |
| 100 mg | $178 | In stock | |
| 200 mg | $248 | In stock | |
| 1 g | Get quote |
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CDDO Methyl ester (NSC 713200, RTA 402, Bardoxolone methyl, CDDO-Me) is a potent activator of Nrf2, inhibits proliferation, induces differentiation and apoptosis in AML cells.
CDDO Methyl ester induces rapid apoptosis (IC50=0.1-0.3 uM) and triggers a series of effects associated with apoptosis including a rapid release of cytochrome c from mitochondria, activation of procaspase-9, -7, -6, and -3, and cleavage of PARP and lamin A/C in NSCLC cells.
CDDO Methyl ester also demonstrates potent antidiabetic activity, reducing proinflammatory cytokine expression in high fat diet-fed type 2 diabetic mice.
| M.Wt | 505.69 | |
| Formula | C32H43NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 49 mg/mL |
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| Chemical Name/SMILES |
Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-, methyl ester |
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1. Konopleva M, et al. Blood. 2002 Jan 1;99(1):326-35.
2. Kim KB, et al. Mol Cancer Ther. 2002 Jan;1(3):177-84.
3. Thimmulappa RK, et al. Antioxid Redox Signal. 2007 Nov;9(11):1963-70.
4. Yates MS, et al. Mol Cancer Ther. 2007 Jan;6(1):154-62.
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