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CDK9-PROTAC

Chemical Structure : CDK9-PROTAC

CAS No.: 2118356-96-8

CDK9-PROTAC

Catalog No.: PC-60100Not For Human Use, Lab Use Only.

CDK9-PROTAC is a heterobifunctional small molecule PROTAC capable of cereblon mediated proteasomal degradation of CDK9.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CDK9-PROTAC is a heterobifunctional small molecule PROTAC capable of cereblon mediated proteasomal degradation of CDK9; selectively degrades CDK9 while sparing other CDK family members in HCT116 cells.

Physicochemical Properties

M.Wt 613.671
Formula C33H35N5O7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(5-cyclobutyl-1H-pyrazol-3-yl)-2-(4-((5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)pentyl)oxy)phenyl)acetamide

References

1. Robb CM, et al. Chem Commun (Camb). 2017 Jul 4;53(54):7577-7580.

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