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Chemical Structure : CFT-2718
Catalog No.: PC-72644Not For Human Use, Lab Use Only.
CFT-2718 (CFT2718) is a benzotriazoloazepine-based BRD4 degrader, rapidly and selectively degrade BRD4 in vitro in a CRBN-dependent manner (DC90=10 nM, 293T cells).
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CFT-2718 (CFT2718) is a benzotriazoloazepine-based BRD4 degrader, rapidly and selectively degrade BRD4 in vitro in a CRBN-dependent manner (DC90=10 nM, 293T cells).
CFT-2718 is more effective than dinaciclib in controlling cell growth and efficiently reduces BRD4 expression in vitro (H69 cell IC50: 0.02 versus 17.38 nM).
CFT-2718 is more effective than dinaciclib in control of PDX tumor models in vivo.
CFT-2718 selectively increased the expression of cleaved PARP, an indicator of apoptosis.
CFT-2718 caused rapid BRD4 degradation and reduced levels of total and pSer2 RPB1 protein.
| M.Wt | 811.388 | |
| Formula | C45H47ClN10O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sun D, et al. Mol Cancer Ther. 2021 Aug;20(8):1367-1377.
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