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Chemical Structure : CHZ-868
CAS No.: 1895895-38-1
Catalog No.: PC-45575Not For Human Use, Lab Use Only.
CHZ-868 (CHZ868) is a potent type II JAK2 inhibitor, inhibits the proliferation of SET2 JAK2 V617F cells (GI50=59 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | $558 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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CHZ-868 (CHZ868) is a potent type II JAK2 inhibitor, inhibits the proliferation of SET2 JAK2 V617F cells (GI50=59 nM).
CHZ-868 (CHZ868) reverses type I JAK inhibitor persistence and demonstrates efficacy in myeloproliferative neoplasms.
CHZ-868 (CHZ868) reduces mutant allele burden in vivo, shows significant efficacy in Jak2V617F-driven polycythemia vera.
CHZ-868 (CHZ868) is orally active.
| M.Wt | 423.4154 | |
| Formula | C22H19F2N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 150 mg/mL |
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| Chemical Name/SMILES |
Acetamide, N-[4-[[2-[(2,4-difluorophenyl)amino]-1,4-dimethyl-1H-benzimidazol-5-yl]oxy]-2-pyridinyl]- |
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1. Meyer SC, et al. Cancer Cell. 2015 Jul 13;28(1):15-28.
2. Wu SC, et al. Cancer Cell. 2015 Jul 13;28(1):29-41.
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