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Chemical Structure : CXCR2-IN-68
Catalog No.: PC-62775Not For Human Use, Lab Use Only.
CXCR2-IN-68 is a potent, selective, brain penetrant, and orally bioavailable CXCR2 antagonist with pIC50 of 9.0, displays 730-fold selectivity over CXCR1 and >1,900-fold selectivity over all other chemokine receptors.
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CXCR2-IN-68 is a potent, selective, brain penetrant, and orally bioavailable CXCR2 antagonist with pIC50 of 9.0, displays 730-fold selectivity over CXCR1 and >1,900-fold selectivity over all other chemokine receptors; inhibits human whole blood Gro-α induced CD11b expression with IC50 of 0.04 µM, 17-fold more potent than Navarixin; significantly inhibits neutrophil infiltration in mouse at 1, 3, 10 mg/kg oral dosing twice daily (BID).
| M.Wt | 414.901 | |
| Formula | C18H23ClN2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lu H, et al. J Med Chem. 2018 Feb 28. doi: 10.1021/acs.jmedchem.7b01854.
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