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Chemical Structure : CYT387
CAS No.: 1056634-68-4
Catalog No.: PC-42751Not For Human Use, Lab Use Only.
Momelotinib (CYT387) is a potent and selective JAK1/JAK2 inhibitor with IC50 of 11/18 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $178 | In stock | |
| 100 mg | Get quote |
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Momelotinib (CYT387) is a potent and selective JAK1/JAK2 inhibitor with IC50 of 11/18 nM.
Momelotinib (CYT387) shows significantly less activity against other kinases, including JAK3 (IC50=155 nM).
Momelotinib (CYT387) inhibits JAK2V617F (JH1-JH2) withIC50 of 11 nM.
Momelotinib (CYT387) inhibits growth of Ba/F3-JAK2V617F and HEL cells (IC50=1500 nM) or Ba/F3-MPLW515L cells (IC50=200 nM).
| M.Wt | 414.4598 | |
| Formula | C23H22N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 40 mg/mL |
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| Chemical Name/SMILES |
Benzamide, N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]- |
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1. Pardanani A, et al. Leukemia. 2009 Aug;23(8):1441-5.
2. Burns CJ, et al. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5887-92.
3. Tyner JW, et al. Blood. 2010 Jun 24;115(25):5232-40.
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