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Cligosiban

Chemical Structure : Cligosiban

CAS No.: 900510-03-4

Cligosiban (PF-3274167;PF 03274167)

Catalog No.: PC-61369Not For Human Use, Lab Use Only.

A potent, specific oxytocin receptor antagonist with Ki of 9.5 nM, displays high selectivity over the vasopressin receptors.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent, specific oxytocin receptor antagonist with Ki of 9.5 nM, displays high selectivity over the vasopressin receptors; demonstrates excellent potency and selectivity, as well as promising in vivo pharmacokinetics and significantly improved aqueous solubility.

Sexual Dysfunction

Phase 1 Discontinued

Physicochemical Properties

M.Wt 419.841
Formula C19H19ClFN5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-(3-(3-(2-chloro-4-fluorophenoxy)azetidin-1-yl)-5-(methoxymethyl)-4H-1,2,4-triazol-4-yl)-2-methoxypyridine

References

1. Vidal B, et al. Nucl Med Biol. 2017 Dec;55:1-6.

2. Brown A, et al. Bioorg Med Chem Lett. 2010 Jan 15;20(2):516-20.

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