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Chemical Structure : Compound F0045 S enantiomer
Catalog No.: PC-38258Not For Human Use, Lab Use Only.
Compound F0045 S enantiomer (F0045(S)) is a novel small-molecule fusion inhibitor of influenza A hemagglutinin (HA), shows EC50 of 0.5-1.9 uM against a panel of group 1 HAs.
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Compound F0045 S enantiomer (F0045(S)) is a novel small-molecule fusion inhibitor of influenza A hemagglutinin (HA), shows EC50 of 0.5-1.9 uM against a panel of group 1 HAs.
Compound F0045 binds to pockets in the HA stem similar to bnAbs FI6v3 and CR9114, cyclic peptide P7, and small-molecule inhibitor JNJ4796.
F0045(S) exhibited in vitro neutralization activity against multiple H1N1 and H5N1 strains.
F0045(S) readily neutralized MDCK-SIAT1 infection by H1/Beijing (EC50=1.6 μM), H1/Cal04 (EC50 =3.9 μM), and H5 A/Vietnam/1203/2004 (EC50 =22.8 μM).
| M.Wt | 336.212 | |
| Formula | C17H15Cl2NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yao Yao, et al. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18431-18438.
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