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Chemical Structure : Cyclopamine tartrate
Catalog No.: PC-63064Not For Human Use, Lab Use Only.
Cyclopamine tartrate is a natural steroidal alkaloid that inhibits hedgehog (Hh) signaling with IC50 of 46 nM.
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Cyclopamine tartrate is a natural steroidal alkaloid that inhibits hedgehog (Hh) signaling with IC50 of 46 nM; inhibits hedgehog-dependent expression of Pax7 with IC50 of 24 nM, blocks the response of neural plate explants to recombinant Shh-N; A useful tool in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.
| M.Wt | 973.32 | |
| Formula | C58H88N2O10 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Peukert S, et al. Bioorg Med Chem Lett. 2009 Jan 15;19(2):328-31.
2. Cooper MK, et al. Science. 1998 Jun 5;280(5369):1603-7.
3. Incardona JP, et al. Development. 1998 Sep;125(18):3553-62.
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