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Chemical Structure : D-alpha-Hydroxyglutaric acid disodium salt
CAS No.: 103404-90-6
Catalog No.: PC-42195Not For Human Use, Lab Use Only.
A competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $56 | In stock | |
| 50 mg | $96 | In stock | |
| 100 mg | $160 | In stock |
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A competitive inhibitor of multiple α-KG-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases; partially and completely inhibits CeKDM7A demethylase at 50 mM and 100 mM, respectively; comptes with α-KG and inhibits KDM5B/JARID1B/PLU-1 with Ki of 10.87 mM; binds and inhibits ATP synthase and inhibit mTOR signaling in IDH1 mutant cells
| M.Wt | 192.08 | |
| Formula | C5H6Na2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
H2O: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
Pentanedioic acid, 2-hydroxy-, disodium salt, (2R)- |
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1. Xu W, et al. Cancer Cell. 2011 Jan 18;19(1):17-30.
2. Fu X, et al. Cell Metab. 2015 Sep 1;22(3):508-15.
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