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Chemical Structure : DBPR112
CAS No.: 1226549-49-0
Catalog No.: PC-73088Not For Human Use, Lab Use Only.
DBPR112 (DBPR 112) is a highly potent, selective inhibitor of EGFR mutant L858R/T790M (IC50=48 nM) and exon 20 insertion mutations.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | $758 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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DBPR112 (DBPR 112) is a highly potent, selective inhibitor of EGFR mutant L858R/T790M (IC50=48 nM) and exon 20 insertion mutations.
DBPR112 inhibited HCC827 cell growth with IC50 of 25 nM, exhibited tenfold potency better than the third-generation inhibitor, osimertinib, against EGFR and HER2 exon 20 insertion mutations.
DBPR112 demonstrated significant antitumor efficacy in in vivo xenograft models.
| M.Wt | 533.632 | |
| Formula | C32H31N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S,E)-4-(dimethylamino)-N-(3-(4-((2-hydroxy-1-phenylethyl)amino)-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl)but-2-enamide |
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1. Shu-Yu Lin, et al. J Med Chem. 2019 Nov 27;62(22):10108-10123.
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