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Chemical Structure : DEBIO 1143
CAS No.: 1071992-99-8
Catalog No.: PC-35889Not For Human Use, Lab Use Only.
DEBIO 1143 (Xevinapant, AT-406, SM406, ARRY-334543, D1143) is a potent, orally active Smac mimetic that antagonizes cIAP1, cIAP2 and XIAP with Ki of 66.4, 1.9 and 5.1 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $138 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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DEBIO 1143 (Xevinapant, AT-406, SM406, ARRY-334543, D1143) is a potent, orally active Smac mimetic that antagonizes cIAP1, cIAP2 and XIAP with Ki of 66.4, 1.9 and 5.1 nM, respectively.
DEBIO 1143 effectively antagonizes XIAP BIR3 protein in cell-free functional assays, induces rapid degradation of cellular cIAP1 protein, and inhibits cancer cell growth in various human cancer cell lines.
DEBIO 1143 effectively induces apoptosis and causes complete inhibition of tumor growth apoptosis in xenograft tumors.
| M.Wt | 561.727 | |
| Formula | C32H43N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide |
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1. Cai Q, et al. J Med Chem. 2011 Apr 28;54(8):2714-26.
2. Langdon CG, et al. Oncotarget. 2015 Nov 10;6(35):37410-25.
3. Tao Z, et al. Clin Cancer Res. 2018 Oct 23. doi: 10.1158/1078-0432.
4. Thibault B, et al. Sci Rep. 2018 Dec 14;8(1):17862.
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