Chemical Structure : DHP-103
CAS No.:
2775311-82-3
DHP-103
(DHP103)
Catalog No.: PC-24526Not For Human Use, Lab Use Only.
DHP-103 is a potent, highly selective inhibitor of intermediate-conductance calcium-activated K+ channel KCa3.1 with IC50 of 6.1 nM, exhibits exquisite selectivity over calcium channels and a panel of >100 additional molecular targets.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DHP-103 is a potent, highly selective inhibitor of intermediate-conductance calcium-activated K+ channel KCa3.1 with IC50 of 6.1 nM, exhibits exquisite selectivity over calcium channels and a panel of >100 additional molecular targets.
DHP-103 binds to the water-filled central cavity of the KCa3.1 channel pore,directly impedes ion permeation.
DHP-103 inhibits gain-of-function mutant KCa3.1 channels that cause hereditary xerocytosis.
DHP-103 administered 12 h postischemic insult in proof-of-concept studies reduced infarct volume, improved balance beam performance (measure of proprioception) and decreased numbers of activated microglia in infarcted areas in rat model of acute ischemic stroke.
Physicochemical Properties
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M.Wt
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359.28
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Formula
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C16H13F4NO4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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dimethyl 4-(4-fluoro-3-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate
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References
1. Ong ST, et al. Proc Natl Acad Sci U S A. 2025 May 6;122(18):e2425494122.
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