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Chemical Structure : DKM 3-42
Catalog No.: PC-35381Not For Human Use, Lab Use Only.
DKM 3-42 is a selective, covalent, in vivo-active ALDH3A1 inhibitor with IC50 of 50 uM against purified human ALDH3A1, targets ALDH3A1 catalytic cysteine, impairs both in situ and in vivo lung cancer pathogenicity.
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DKM3-42 is a selective, covalent, in vivo-active ALDH3A1 inhibitor with IC50 of 50 uM against purified human ALDH3A1, targets ALDH3A1 catalytic cysteine, impairs both in situ and in vivo lung cancer pathogenicity.
DKM3-42 impairs A549 serum-survival in a dose-responsive manner.
DKM3-42 significantly attenuates tumor growth in vivo in A549 tumor xenografts in mice with dose of 50mg/kg ip, once per day.
| M.Wt | 207.317 | |
| Formula | C13H21NO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Counihan JL, et al. ACS Chem Biol. 2018 Jul 13. doi: 10.1021/acschembio.8b00381.
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