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Chemical Structure : DM509
Catalog No.: PC-61057Not For Human Use, Lab Use Only.
DM509 is a potent, orally active dual modulator of FXR and soluble epoxide hydrolase (sEH) that exertss partial FXR agonism (pEC50=7.7) and sEH inhibitory activity (pIC50=8.4).
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DM509 is a potent, orally active dual modulator of FXR and soluble epoxide hydrolase (sEH) that exertss partial FXR agonism (pEC50=7.7) and sEH inhibitory activity (pIC50=8.4).
DM509 demonstrates antisteatotic and antifibrotic effects and potential for nonalcoholic steatohepatitis (NASH) management with low toxicity, and pilot in vivo data revealed favorable pharmacokinetics.
| M.Wt | 394.914 | |
| Formula | C19H23ClN2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Schmidt J, et al. J Med Chem. 2017 Sep 28;60(18):7703-7724.
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