Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : DNL201
CAS No.: 1374828-69-9
Catalog No.: PC-38909Not For Human Use, Lab Use Only.
DNL201 (GNE0877) is a first-in-class, CNS-penetrant, selective, ATP-competitive, small-molecule LRRK2 kinase inhibitor with IC50 of 3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $548 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
DNL201 (GNE0877) is a first-in-class, CNS-penetrant, selective, ATP-competitive, small-molecule LRRK2 kinase inhibitor with IC50 of 3 nM.
DNL201 inhibited LRRK2 kinase activity by reduced phosphorylation of both LRRK2 at serine-935 (pS935) and Rab10 at threonine-73 (pT73), a direct substrate of LRRK2.
DNL201 demonstrated improved lysosomal function in cellular models of disease, including primary mouse astrocytes and fibroblasts from patients with Gaucher disease.
DNL201 shows the potential to correct lysosomal dysfunction in patients with Parkinson's disease (PD) in clinical investigations.
| M.Wt | 339.326 | |
| Formula | C14H16F3N7 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-methyl-2-(3-methyl-4-((4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)propanenitrile |
|
1. Jennings D, et al. Sci Transl Med. 2022 Jun 8;14(648):eabj2658.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
