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Chemical Structure : DSM421
Catalog No.: PC-60459Not For Human Use, Lab Use Only.
DSM421 is a potent, selective P. falciparum dihydroorotate dehydrogenase (PfDHODH) with IC50 of 53 nM.
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DSM421 is a potent, selective P. falciparum dihydroorotate dehydrogenase (PfDHODH) with IC50 of 53 nM.
DSM421 does not inhibits human enzymes.
DSM421 inhibits Pf 3D7 with EC50 of 14 nM, has improved drug-like properties and better species selectivity relative to DSM265, whilst maintaining efficacy and pharmacokinetic properties .
| M.Wt | 357.288 | |
| Formula | C15H12F5N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Phillips MA, et al. ACS Infect Dis. 2016 Dec 9;2(12):945-957.
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