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Chemical Structure : DWP16001
CAS No.: 1415472-28-4
Catalog No.: PC-72663Not For Human Use, Lab Use Only.
DWP16001 (Enavogliflozin, GCC 5694A) is a potent and selective sodium glucose co-transporter 2 (SGLT-2) inhibitor with IC50 of 0.46 nM (hSGLT2), > 700-fold selectivity against SGLT1.
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|---|---|---|---|
| 5 mg | $428 | In stock | |
| 10 mg | $728 | In stock | |
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| 100 mg | Get quote | ||
| 1 g | Get quote |
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DWP16001 (Enavogliflozin, GCC 5694A) is a potent and selective sodium glucose co-transporter 2 (SGLT-2) inhibitor with IC50 of 0.46 nM (hSGLT2), > 700-fold selectivity against SGLT1.
GCC5694A exhibited activity comparable to that of dapagliflozin.
Oral administration of GCC5694A (0.1–1 mg/kg) increased urinary glucose excretion in a dose-dependent manner.
In STZ-induced type 1 diabetic rats and type 2 diabetic db/db mice, repeated administration of GCC5694A (0.05–0.5 mg/kg) for 5 weeks significantly reduced the levels of hemoglobin A1c (HbA1c) and blood glucose.
| M.Wt | 446.924 | |
| Formula | C24H27ClO6 | |
| Appearance | Solid | |
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| Chemical Name/SMILES |
D-Glucitol, 1,5-anhydro-1-C-[7-chloro-6-[(4-cyclopropylphenyl)methyl]-2,3-dihydro-4-benzofuranyl]-, (1S)- |
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1. Young Kyu Kong, et al. Bioorg Med Chem Lett. 2022 Jan 15;56:128466.
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