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Chemical Structure : Deltasonamide 2
Catalog No.: PC-61154Not For Human Use, Lab Use Only.
Deltasonamide 2 (Deltasonamide-2) is a novel small molecule inhibitor of PDE6δ/KRas interaction with Kd of 385 pM.
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Deltasonamide 2 (Deltasonamide-2) is a novel small molecule inhibitor of PDE6δ/KRas interaction with Kd of 385 pM; inhibits PDE6δ/KRas interaction in cells with Kd of 64 nM, selectively inhibits growth of KRas mutated and -dependent cells, inhibits the oncogenic KRas-dependent MiaPaCa-2 with IC50 of 750 nM.
| M.Wt | 647.25 | |
| Formula | C30H39ClN6O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Martín-Gago P, et al. Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2423-2428.
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