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Chemical Structure : Deucravacitinib
CAS No.: 1609392-27-9
Catalog No.: PC-73037Not For Human Use, Lab Use Only.
BMS-986165 (Deucravacitinib, BMS986165) is potent, high selective allosteric inhibitor of TYK2 with Ki of 0.02 nM, IC50 of 0.2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $368 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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BMS-986165 (Deucravacitinib, BMS986165) is potent, high selective allosteric inhibitor of TYK2 with Ki of 0.02 nM, IC50 of 0.2 nM.
BMS-986165 binds to the TYK2 pseudokinase (JH2) domain, displays unprecedented JAK isoform and kinome selectivity.
BMS-986165 shows excellent pharmacokinetic properties with minimal profiling liabilities and is efficacious in several murine models of autoimmune disease.
| M.Wt | 425.47 | |
| Formula | C20H19D3N8O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide |
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1. Wrobleski ST, et al. J Med Chem. 2019 Oct 24;62(20):8973-8995.
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