Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : EB‐42486
CAS No.: 2390475-81-5
Catalog No.: PC-21887Not For Human Use, Lab Use Only.
EB‐42486 is a potent, selective G2019S-LRRK2 kinase inhibitor with IC50 of 3.1 nM (pS935-LRRK2) in FRET-based assay, >300-fold selective over WT-LRRR2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $328 | In stock | |
| 10 mg | $528 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
EB‐42486 is a potent, selective G2019S-LRRK2 kinase inhibitor with IC50 of 3.1 nM (pS935-LRRK2) in FRET-based assay, >300-fold selective over WT-LRRR2.
EB‐42486 potently inhibits pS1292-LRRK2 G2019S in Meso Scale Discovery (MSD) electrochemiluminescence assay with IC50 of 1.7 nM, 70-fold selective over WT LRRK2.
EB‐42486 exhibits impressive kinome selectivity against a panel of 409 kinases at 100 nM.
EB‐42486 inhibits phosphorylation of the LRRK2 substrate, Rab10, 344-fold more potently in the G2019S-LRRK2 overexpression line with IC50 of 11.4 nM, compared to that in the WT-LRRK2 overexpression line.
EB‐42486 inhibits pS935-LRRK2 837-fold more potently in the G2019S-LRRK2 line (IC50 = 2.5 nM) compared to that in the WT-LRRK2 line.
| M.Wt | 414.47 | |
| Formula | C22H22N8O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4,5,7,7-Tetramethyl-N-(3-phenyl-1H-indazol-5-yl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide |
|
1. Albert W Garofalo, et al. J Med Chem. 2020 Dec 10;63(23):14821-14839.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
