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Chemical Structure : EMD-281014 hydrochloride
Catalog No.: PC-35384Not For Human Use, Lab Use Only.
EMD-281014 hydrochloride ((Pruvanserin, LSN2411347, LY-2422347)) is a potent, highly selective 5-HT2A antagonist with Ki of 0.87 nM, displays little to no affinity for 5-HT2C receptors (Ki=557 nM), human D2 receptors and IKr channels.
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EMD-281014 hydrochloride ((Pruvanserin, LSN2411347, LY-2422347)) is a potent, highly selective 5-HT2A antagonist with Ki of 0.87 nM, displays little to no affinity for 5-HT2C receptors (Ki=557 nM), human D2 receptors and IKr channels; significantly increases swimming and decreases immobility in male congenital learned helpless rats in the forced swim test; reduces dyskinesia and psychosis in the l-DOPA-treated parkinsonian marmoset.
Sleep Disorder
Discontinued
| M.Wt | 412.893 | |
| Formula | C22H22ClFN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hamadjida A, et al. Neuropharmacology. 2018 Jun 30;139:61-67.
2. Lauffer L, et al. J Pharmacol Exp Ther. 2016 Jul;358(1):39-49.
3. Patel JG, et al. Synapse. 2004 Apr;52(1):73-5.
4. Ladduwahetty T, et al. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3201-4.
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