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Chemical Structure : Endovion
CAS No.: 265646-85-3
Catalog No.: PC-38096Not For Human Use, Lab Use Only.
Endovion (Emidurdar, NS3728) is a volume-regulated anion channel (VRAC) blocker with IC50 of 460 nM.
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Endovion (Emidurdar, NS3728) is a volume-regulated anion channel (VRAC) blocker with IC50 of 460 nM.
NS3728 blocks red blood cell chloride conductance (IC50 = 0.6 μM).
NS 3728 also inhibits Ca2+-activated Cl- current (CaCC) by anoctamin (ANO) in an apparently voltage-dependent manner (IC50 against ANO1 = 2.1 and 0.7 μM at -95 and +50 mV, respectively).
| M.Wt | 495.18 | |
| Formula | C16H9BrF6N6O | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Klausen TK, et al. J Cell Physiol. 2007 Mar;210(3):831-42.
2. Schneider L, et al. Pflugers Arch. 2008 Mar;455(6):1055-62.
3. Kjaer K, et al. Brain Res. 2009 Jul 24;1281:15-24.
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