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Chemical Structure : FRAX-1036
CAS No.: 1432908-05-8
Catalog No.: PC-45644Not For Human Use, Lab Use Only.
FRAX1036 is a potent and selective inhibitor of group I PAKs (PAK1, Ki=23.3 nM; PAK2, Ki=72.4 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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FRAX1036 is a potent and selective inhibitor of group I PAKs (PAK1, Ki=23.3 nM; PAK2, Ki=72.4 nM).
FRAX1036 displays weak affinity on PAK4 (Ki = 2.4 uM).
FRAX1036 inhibits phosphorylation of MEK1-S298 and CRAF-S338 at 2.5-5 uM in MDA-MB-175 cells.
FRAX1036 inhibits MPNST cell growth in vitro and dramatically decreases local and metastatic MPNST growth in animal models combined with PD0325901.
| M.Wt | 518.053 | |
| Formula | C28H32ClN7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 5.3 mg/mL (Need warming) |
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| Chemical Name/SMILES |
Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-[2-chloro-4-(6-methyl-2-pyrazinyl)phenyl]-8-ethyl-2-[[2-(1-methyl-4-piperidinyl)ethyl]amino]- |
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1. Ong CC, et al. Breast Cancer Res. 2015 Apr 23;17:59.
2. Mortazavi F, et al. BMC Cancer. 2015 May 9;15:381.
3. Semenova G, et al. Oncogene. 2017 May 22. doi: 10.1038/onc.2017.143.
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