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Chemical Structure : Filibuvir
Catalog No.: PC-61888Not For Human Use, Lab Use Only.
Filibuvir (PF-00868554.
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Filibuvir (PF-00868554;PF-868554) is a nonnucleoside, potent and selective, orally available HCV NS5B inhibitor with IC50 of 19 nM, EC50 of 75 nM (genotype 1b-Con1 replicon); has potent in vitro antiviral activity against a majority (95.8%) of genotype 1a and 1b replicons with an overall mean EC50 of 59 nM, without cytotoxic effect in several human cell lines (CC50>320 uM); exhibits good pharmacokinetic properties in preclinical animal species.
HCV Infection
Phase 2 Discontinued
| M.Wt | 503.636 | |
| Formula | C29H37N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Li H, et al. J Med Chem. 2009 Mar 12;52(5):1255-8.
2. Shi ST, et al. Antimicrob Agents Chemother. 2009 Jun;53(6):2544-52.
3. Wagner F, et al. Hepatology. 2011 Jul;54(1):50-9. doi: 10.1002/hep.24342.
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