Foretinib-Based PROTAC 7 |CAS:2230821-68-6 Probechem Biochemicals

Chemical Structure : Foretinib-Based PROTAC 7

Catalog No.: PC-35356Not For Human Use, Lab Use Only.

Foretinib-Based PROTAC 7 is a VHL-recruiting PROTAC that induces the degradation of c-Met in a dose- and time-dependent fashion in MDA-MB-231 cells..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Foretinib-Based PROTAC 7 is a VHL-recruiting PROTAC that induces the degradation of c-Met in a dose- and time-dependent fashion in MDA-MB-231 cells.

M.Wt	1106.253
Formula	C58H65F2N7O11S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-fluoro-4-((7-(3-(3-(3-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propoxy)propoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dic

1. Burslem GM, et al. Cell Chem Biol. 2018 Jan 18;25(1):67-77.e3.