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Chemical Structure : Fumarase-IN-1
CAS No.: 1644060-37-6
Catalog No.: PC-42018Not For Human Use, Lab Use Only.
A cell-permeable small molecule inhibitor of Fumarase (fumarate hydratase), an enzyme of the tricarboxylic acid cycle (TCA cycle).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $176 | In stock | |
| 10 mg | $256 | In stock | |
| 50 mg | $784 | In stock | |
| 100 mg | $1320 | In stock |
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A cell-permeable small molecule inhibitor of Fumarase (fumarate hydratase), an enzyme of the tricarboxylic acid cycle (TCA cycle); elicits a nutrient-dependent cytotoxicity in a number of cancer cell lines, and displays increased growth-inhibitory activity toward SW620 cell line grown in the absence of glucose.
| M.Wt | 446.5381 | |
| Formula | C27H30N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3aH-Indole-3a-carboxylic acid, 1-([1,1'-biphenyl]-4-ylmethyl)-1,2,3,4,5,6-hexahydro-3-[2-(methylamino)-2-oxoethyl]-2-oxo-, ethyl ester, (3R,3aS)-rel- |
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1. Takeuchi T, et al. J Am Chem Soc. 2015 Jan 21;137(2):564-7.
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