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Chemical Structure : Fusicoccin-A
Catalog No.: PC-61233Not For Human Use, Lab Use Only.
Fusicoccin-A is a small-molecule stabilizer of 14-3-3 protein-protein interactions that stabilizes the complex between 14-3-3 and the stress response regulator GCN1.
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Fusicoccin-A is a small-molecule stabilizer of 14-3-3 protein-protein interactions that stabilizes the complex between 14-3-3 and the stress response regulator GCN1.
Fusicoccin-A induces GCN1 turnover and neurite outgrowth, stimulates axon growth in vitro and regeneration in vivo.
Fusicoccin-A stabilizes the interaction between 14-3-3 and CFTR by selectively interacting with a secondary binding motif of CFTR (pS753).
| M.Wt | 680.82 | |
| Formula | C36H56O12 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kaplan A, et al. Neuron. 2017 Mar 8;93(5):1082-1093.e5.
2. Stevers LM, et al. Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1152-61.
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