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Chemical Structure : Fuzuloparib
CAS No.: 1358715-18-0
Catalog No.: PC-36037Not For Human Use, Lab Use Only.
Fluzoparib (Fuzuloparib, SHR-3162) is a novel, potent and orally available inhibitor of PARP with IC50 of 1.46 nM (PARP1).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $358 | In stock | |
| 100 mg | $858 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Fluzoparib (Fuzuloparib, SHR-3162) is a novel, potent and orally available inhibitor of PARP with IC50 of 1.46 nM (PARP1).
Fluzoparib (Fuzuloparib, SHR-3162) potently inhibited PARP1 enzyme activity and induced DNA double-strand breaks, G2/M arrest and apoptosis in homologous recombination repair (H)-deficient cells.
Fluzoparib (Fuzuloparib, SHR-3162) preferentially inhibited the proliferation of HR-deficient cells and sensitized both HR-deficient and HR-proficient cells to cytotoxic drugs.
Fluzoparib (Fuzuloparib, SHR-3162) demonstrates superior anti-tumor activity in HR-deficient xenografts models, elicited significantly improved anti-tumor responses without extra toxicity in combination with apatinib or with apatinib plus paclitaxel.
| M.Wt | 472.404 | |
| Formula | C22H16F4N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(4-fluoro-3-(2-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-7-carbonyl)benzyl)phthalazin-1(2H)-one |
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1. Wang L, et al. Cancer Sci. 2019 Jan 21. doi: 10.1111/cas.13947.
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