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Chemical Structure : GAC0001E5
Catalog No.: PC-49867Not For Human Use, Lab Use Only.
GAC0001E5 (LXR ligand 1E5) is a small molecule liver X receptor (LXR) inverse agonist and a potent inhibitor of pancreatic and breast cancer cells (MDA-MB-231, IC50=7.74 uM).
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GAC0001E5 (LXR ligand 1E5) is a small molecule liver X receptor (LXR) inverse agonist and a potent inhibitor of pancreatic and breast cancer cells (MDA-MB-231, IC50=7.74 uM).
GAC0001E5 significantly decreased LXRβ transcription and translation in MCF7-TamR and MDA-MB-231 cells.
GAC0001E5 induces oxidative stress in breast cancer cells, disrupting glutaminolysis, downregulates the intracellular glutamate levels.
Combination treatment of 1E5 with GLS inhibitor BPTES synergistically decreases glutaminolysis and growth of PDAC cells.
| M.Wt | 331.30 | |
| Formula | C17H12F3N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Srivastava S, et al. Int J Mol Sci. 2020 Dec 17;21(24):9622.
2. Premaratne A, et al. Biomolecules. 2023 Feb 10;13(2):345.
3. araboga H, et al.ACS Chem. Biol. 2020;15:2916–2928.
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