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Chemical Structure : GDC-0941
CAS No.: 957054-30-7
Catalog No.: PC-45820Not For Human Use, Lab Use Only.
Pictilisib (GSC-0941) is a potent, selective, orally bioavailable inhibitor of class I PI3Ks with IC50 of 3/33/3/75 nM for p110α/β/γ/δ, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | Get quote |
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Pictilisib (GSC-0941) is a potent, selective, orally bioavailable inhibitor of class I PI3Ks with IC50 of 3/33/3/75 nM for p110α/β/γ/δ, respectively.
Pictilisib (GSC-0941) shows similar activity for mutant p110α E545K and H1047R (IC50=3 nM), weak or little activity for C2α, Vps34, DNA-PK, and mTOR (IC50>500 nM).
Pictilisib (GSC-0941) inhibits Akt (Ser473) phosphorylation in U87MG, PC3, and MDA-MB-361 cells with IC50s of 46, 37, and 28 nM, respectively, and respective GI50 is 0.95, 0.28, and 0.72 uM.
Pictilisib (GSC-0941) exhibits tumor growth inhibition in U87MG human glioblastoma xenografts.
| M.Wt | 513.6356 | |
| Formula | C23H27N7O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 29 mg/mL |
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| Chemical Name/SMILES |
Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)- |
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1. Folkes AJ, et al. J Med Chem. 2008 Sep 25;51(18):5522-32.
2. Junttila TT, et al. Cancer Cell. 2009 May 5;15(5):429-40.
3. Raynaud FI, et al. Mol Cancer Ther. 2009 Jul;8(7):1725-38.
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