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Chemical Structure : GLPG-1837
CAS No.: 1654725-02-6
Catalog No.: PC-60232Not For Human Use, Lab Use Only.
A potent, orally available CFTR potentiator with EC50 of 3 nM and 339 nM on F508del and G551D CFTR, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $245 | In stock | |
| 25 mg | $695 | In stock | |
| 100 mg | $1485 | In stock | |
| 500 mg | Get quote |
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GLPG-1837 (ABBV-974) is a potent, orally available CFTR potentiator with EC50 of 3 nM and 339 nM on F508del and G551D CFTR, respectively; shows enhanced efficacy on CFTR mutants harboring Class III mutations compared to Ivacaftor.
Cystic Fibrosis
Phase 2 Clinical
| M.Wt | 348.421 | |
| Formula | C16H20N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(3-carbamoyl-5,5,7,7-tetramethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-1H-pyrazole-5-carboxamide |
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1. Van der Plas SE, et al. J Med Chem. 2017 Nov 17. doi: 10.1021/acs.jmedchem.7b01288.
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