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Chemical Structure : GNE-9605
CAS No.: 1536200-31-3
Catalog No.: PC-42945Not For Human Use, Lab Use Only.
GNE-9605 is a highly potent, selective, brain penetrant LRRK2 inhibitor with Ki of 2 nM, pLRRK2 IC50 of 19 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $125 | In stock | |
| 25 mg | $365 | In stock | |
| 100 mg | $985 | In stock | |
| 500 mg | Get quote |
Bulk size, bulk discount!
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GNE-9605 is a highly potent, selective, brain penetrant LRRK2 inhibitor with Ki of 2 nM, pLRRK2 IC50 of 19 nM; dispalys excellent selectivity against 178-membered Invitrogen kinase panel, as well as a representative panel of receptors and ion channels; demonstrates robust concentration-dependent inhibition of LRRK2 Ser1292 autophosphorylation (IC50=20 nM) in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation.
| M.Wt | 449.8336 | |
| Formula | C17H20ClF4N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 60 mg/mL |
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| Chemical Name/SMILES |
2,4-Pyrimidinediamine, N2-[5-chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-, rel- |
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1. Estrada AA, et al. J Med Chem. 2014 Feb 13;57(3):921-36.
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