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Chemical Structure : GPC-100 hydrobromide
CAS No.: 1191450-19-7
Catalog No.: PC-21292Not For Human Use, Lab Use Only.
GPC-100 (TG-0054, Burixafor) is a novel small molecule antagonist of CXCR4, shows competitive inhibition of CXCL12 binding to CXCR4 with Ki of 1.6 nM.
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|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $488 | In stock | |
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| 100 mg | Get quote |
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GPC-100 (TG-0054, Burixafor) is a novel small molecule antagonist of CXCR4, shows competitive inhibition of CXCL12 binding to CXCR4 with Ki of 1.6 nM.
GPC-100 (TG-0054, Burixafor) demonstrates distinct divergence from AMD3100, and has a higher affinity for CXCR4 than AMD3100 (Ki=40 nM).
GPC-100 (TG-0054, Burixafor) dose dependenlyt inhibits CXCL12-induced calcium flux in MDA-MB-231 cells overexpressing CXCR4 with IC50 value of 30 nM.
GPC-100 (TG-0054, Burixafor) inhibits CXCL12 mediated recruitment of β-arrestin to CXCR4 with IC50 value of 207 nM in the PRESTO-TANGO β-arrestin assay.
GPC-100 (TG-0054, Burixafor) efficiently blocks CXCL12-mediated migration in U937 and MM.1S cells with IC50 of 48 nM and 28 nM, respectively.
| M.Wt | 647.64 | |
| Formula | C27H52BrN8O3P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Phosphonic acid, P-[2-[4-[6-amino-2-[[[trans-4-[[[3-(cyclohexylamino)propyl]amino]methyl]cyclohexyl]methyl]amino]-4-pyrimidinyl]-1-piperazinyl]ethyl]-, hydrobromide |
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1. Sukhtankar DD, et al. PLoS One. 2023 Oct 25;18(10):e0287863.
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