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Chemical Structure : GPI-1046
CAS No.: 186452-09-5
Catalog No.: PC-63577Not For Human Use, Lab Use Only.
GPI-1046 is a non-immunosuppressive ligand of the immunophilin FKBP12.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $348 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GPI-1046 is a non-immunosuppressive ligand of the immunophilin FKBP12.
GPI-1046 induces ARNT expression with subsequent activation of ALK3-dependent canonical BMP signaling responses and attenuates chronic organ failure in models of chronic kidney, but also cardiac and liver injuries; reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats.
| M.Wt | 360.454 | |
| Formula | C20H28N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(3-pyridyl)-1-propyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate |
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1. Sauer H, et al. Brain Res. 1999 Sep 18;842(1):109-18.
2. Burnett AL, et al. Urology. 2005 May;65(5):1003-7.
3. Sari Y, et al. Neuroscience. 2012 Dec 27;227:327-35.
4. Tampe B, et al. J Clin Invest. 2018 Apr 17. pii: 89632.
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