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Chemical Structure : GSK-1016790A
CAS No.: 942206-85-1
Catalog No.: PC-45654Not For Human Use, Lab Use Only.
GSK-1016790A is a potent TRPV4 channel agonist, induces Ca2+ influx in HEK cells expressing human TRPV4 with EC50 of 2.1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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GSK-1016790A is a potent TRPV4 channel agonist, induces Ca2+ influx in HEK cells expressing human TRPV4 with EC50 of 2.1 nM.
GSK-1016790A displays no effect on TRPM8 and TRPA1.
GSK-1016790A evokes a dose-dependent activation of TRPV4 whole-cell currents at >1 nM, 300-fold more potent than 4alpha-PDD.
GSK-1016790A induces urinary bladder contraction and hyperactivity in TRPV4+/+ mice.
| M.Wt | 655.613 | |
| Formula | C28H32Cl2N4O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
Benzo[b]thiophene-2-carboxamide, N-[(1S)-1-[[4-[(2S)-2-[[(2,4-dichlorophenyl)sulfonyl]amino]-3-hydroxy-1-oxopropyl]-1-piperazinyl]carbonyl]-3-methylbutyl]- |
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1. Thorneloe KS, et al. J Pharmacol Exp Ther. 2008 Aug;326(2):432-42.
2. Rajasekhar P, et al. J Biol Chem. 2015 Nov 27;290(48):29051-62.
3. Hong Z, et al. Mol Neurobiol. 2016 Jan;53(1):759-768.
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