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Chemical Structure : GSK-180736A
CAS No.: 817194-38-0
Catalog No.: PC-45590Not For Human Use, Lab Use Only.
A highly selective and potent GRK2 inhibitor with IC50 of 0.77 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $72 | In stock | |
| 10 mg | $96 | In stock | |
| 50 mg | $320 | In stock | |
| 100 mg | $600 | In stock |
Bulk size, bulk discount!
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A highly selective and potent GRK2 inhibitor with IC50 of 0.77 uM; displays >400-fold selective for GRK2 over both GRK1 and GRK5, with no inhibition on PKA; also inhibits ROCK with IC50 of 0.1 uM.
| M.Wt | 365.3611 | |
| Formula | C19H16FN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
5-Pyrimidinecarboxamide, 4-(4-fluorophenyl)-1,2,3,4-tetrahydro-N-1H-indazol-5-yl-6-methyl-2-oxo- |
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1. Homan KT, et al. ACS Chem Biol. 2015 Jan 16;10(1):310-9.
2. Waldschmidt HV, et al. J Med Chem. 2016 Apr 28;59(8):3793-807.
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