Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : GSK-199
CAS No.: 1549810-81-2
Catalog No.: PC-62216Not For Human Use, Lab Use Only.
GSK-199 is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 250 nM in FP binding assay (0.2 mM Ca), 200 nM in PAD4 NH3 release inhibition assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $448 | In stock | |
| 50 mg | $728 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
GSK-199 is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 250 nM in FP binding assay (0.2 mM Ca), 200 nM in PAD4 NH3 release inhibition assay.
GSK-199 shows high specificity for PAD4 over PAD1/2/3/6.
GSK-199 affects cellular citrullination and mimic the deficiency in NET production in mice.
GSK-199 significantly decreases in complement C3 deposition in both synovium and cartilage in mice.
| M.Wt | 432.528 | |
| Formula | C24H28N6O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
[(3R)-3-amino-1-piperidinyl][2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-methanone |
|
1. Lewis HD, et al. Nat Chem Biol. 2015 Mar;11(3):189-91.
2. Willis VC, et al. Clin Exp Immunol. 2017 May;188(2):263-274.
3. Slade DJ, et al. ACS Chem Biol. 2015 Apr 17;10(4):1043-53.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
