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Chemical Structure : GSK-199 hydrochloride
CAS No.: 1549811-53-1
Catalog No.: PC-62217Not For Human Use, Lab Use Only.
GSK-199 hydrochloride is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 250 nM in FP binding assay (0.2 mM Ca), 200 nM in PAD4 NH3 release inhibition assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $388 | In stock | |
| 25 mg | $598 | In stock | |
| 100 mg | $1480 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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GSK-199 hydrochloride is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 250 nM in FP binding assay (0.2 mM Ca), 200 nM in PAD4 NH3 release inhibition assay.
GSK-199 shows high specificity for PAD4 over PAD1/2/3/6.
GSK-199 affects cellular citrullination and mimic the deficiency in NET production in mice.
GSK-199 significantly decreases in complement C3 deposition in both synovium and cartilage in mice.
GSK199 also inhibits human beta-coronaviruse HCoV-OC43 replication.
| M.Wt | 468.986 | |
| Formula | C24H29ClN6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
[(3R)-3-amino-1-piperidinyl][2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-methanone monohydrochloride |
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1. Lewis HD, et al. Nat Chem Biol. 2015 Mar;11(3):189-91.
2. Willis VC, et al. Clin Exp Immunol. 2017 May;188(2):263-274.
3. Slade DJ, et al. ACS Chem Biol. 2015 Apr 17;10(4):1043-53.
4. Selina Pasquero, et al. Antiviral Res. 2022 Mar 11;200:105278.
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