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Chemical Structure : GSK-2193874
CAS No.: 1336960-13-4
Catalog No.: PC-60294Not For Human Use, Lab Use Only.
GSK-2193874 (GSK2193874) is an orally active, potent, and selective blocker of TRPV4 channel with IC50 of 40 nM and 2 nM for hTRPV4 and rTRPV4, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $248 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | $728 | In stock | |
| 500 mg | Get quote |
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GSK-2193874 (GSK2193874) is an orally active, potent, and selective blocker of TRPV4 channel with IC50 of 40 nM and 2 nM for hTRPV4 and rTRPV4, respectively; shows high selectivity against TRPV1, TRPA1, TRPC3, TRPC6, TRPM8 (IC50>25 uM); the first-in-class orally bioavailable TRPV4 inhibitor which demonstrates ability to improve pulmonary functions in a number of heart failure models.
| M.Wt | 691.62 | |
| Formula | C37H38BrF3N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(1,4'-bipiperidin-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide |
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1. Cheung M, et al. ACS Med Chem Lett. 2017 Mar 20;8(5):549-554.
2. Buday T, et al. Respir Physiol Neurobiol. 2017 Feb;236:1-4.
3. Thorneloe KS, et al. Sci Transl Med. 2012 Nov 7;4(159):159ra148.
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