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Chemical Structure : GSK-256066 2,2,2-trifluoroacetic acid
CAS No.: 1415560-64-3
Catalog No.: PC-45952Not For Human Use, Lab Use Only.
A potent, selective PDE4 inhibitor with pIC50 of 11.5, 11.3, 11.4, and 11.9 for PDE4B, A, C, and D, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $200 | In stock | |
| 50 mg | $576 | In stock |
Bulk size, bulk discount!
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A potent, selective PDE4 inhibitor with pIC50 of 11.5, 11.3, 11.4, and 11.9 for PDE4B, A, C, and D, respectively; displays >380,000-fold selectivity over PDE1/23/5/6/7; inhibits TNFα production by lLPS-stimulated human peripheral blood monocytes with IC50 of 0.01 nM; inhibites LPS-induced pulmonary neutrophilia with ED50 of 1.1 ug/kg (aqueous suspension) and 2.9 ug/kg (dry powder formulation) in rats.
COPD
Phase 2 Discontinued
| M.Wt | 632.6075 | |
| Formula | C29H27F3N4O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-Quinolinecarboxamide, 6-[[3-[(dimethylamino)carbonyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methyl-, 2,2,2-trifluoroacetate (1:1) |
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1. Woodrow MD, et al. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5261-5.
2. Tralau-Stewart CJ, et al. J Pharmacol Exp Ther. 2011 Apr;337(1):145-54.
3. Nials AT, et al. J Pharmacol Exp Ther. 2011 Apr;337(1):137-44.
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