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Chemical Structure : GSK-484
CAS No.: 1652629-23-6
Catalog No.: PC-62214Not For Human Use, Lab Use Only.
GSK-484 is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 80 nM in FP binding assay (0.2 mM Ca), 50 nM in PAD4 NH3 release inhibition assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | $588 | In stock | |
| 100 mg | Get quote |
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GSK-484 is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 80 nM in FP binding assay (0.2 mM Ca), 50 nM in PAD4 NH3 release inhibition assay.
GSK-484 shows high specificity for PAD4 over PAD1/2/3/6.
GSK-484 causes a clear, statistically-significant reduction in diffused NETs.
| M.Wt | 473.577 | |
| Formula | C27H31N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
[(3S,4R)-3-amino-4-hydroxy-1-piperidinyl][2-[1-(cyclopropylmethyl)-1H-indol-2-yl]-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-methanone |
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1. Lewis HD, et al. Nat Chem Biol. 2015 Mar;11(3):189-91.
2. Cedervall J, et al. Oncoimmunology. 2017 Apr 20;6(8):e1320009.
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