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Chemical Structure : GSK-7975A
CAS No.: 1253186-56-9
Catalog No.: PC-70096Not For Human Use, Lab Use Only.
GSK-7975A (GSK7975A) is a selective CRAC channel blocker that inhibits store-operated Ca(2+) entry (SOCE) with IC50 of 3.4 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $488 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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GSK-7975A (GSK7975A) is a selective CRAC channel blocker that inhibits store-operated Ca(2+) entry (SOCE) with IC50 of 3.4 uM.
GSK-7975A shows little or no effect on the physiological Ca(2+) spiking evoked by acetylcholine or cholecystokinin.
GSK-7975A inhibits the release of mast cell mediators and T-cell cytokines from multiple human and rat preparations.
| M.Wt | 397.305 | |
| Formula | C18H12F5N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,6-difluoro-N-(1-(4-hydroxy-2-(trifluoromethyl)benzyl)-1H-pyrazol-3-yl)benzamide |
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1. Gerasimenko JV, et al. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13186-91.
2. Rice LV, et al. Eur J Pharmacol. 2013 Mar 15;704(1-3):49-57.
3. Derler I, et al. Cell Calcium. 2013 Feb;53(2):139-51.
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