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Chemical Structure : GW-6471
CAS No.: 880635-03-0
Catalog No.: PC-62872Not For Human Use, Lab Use Only.
GW-6471 is a potent PPARα antagonist with IC50 of 0.24 uM, enhances the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR..
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $178 | In stock | |
| 25 mg | $288 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GW-6471 is a potent PPARα antagonist with IC50 of 0.24 uM, enhances the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR.
| M.Wt | 619.685 | |
| Formula | C35H36F3N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-((2S)-2-(((1Z)-1-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)prop-1-enyl)amino)-3-(4-(2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy)phenyl)propyl)propanamide |
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1. Müller MQ, et al. J Med Chem. 2009 May 14;52(9):2875-9.
2. Xu HE, et al. Nature. 2002 Feb 14;415(6873):813-7.
3. Muoio DM, et al. J Biol Chem. 2002 Jul 19;277(29):26089-97.
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