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Chemical Structure : GW-7647
Catalog No.: PC-62445Not For Human Use, Lab Use Only.
GW-7647 is a potent, selective PPARα agonist with EC50 of 6 nM, dispalys high selectivity over PPARγ and PPARδ.
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GW-7647 is a potent, selective PPARα agonist with EC50 of 6 nM, dispalys high selectivity over PPARγ and PPARδ; shows potent lipid-lowering activity in animal models of dyslipidemia; also inhibits USP1/UAF1 noncompetitively with Ki of 0.7 uM; displays selectivity against a number of deubiquitinases, deSUMOylase, and cysteine proteases; reduces LPS-induced NO production.
| M.Wt | 502.758 | |
| Formula | C29H46N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chen J, et al. Chem Biol. 2011 Nov 23;18(11):1390-400.
2. Brown PJ, et al. Bioorg Med Chem Lett. 2001 May 7;11(9):1225-7.
3. Paukkeri EL, et al. Br J Pharmacol. 2007 Dec;152(7):1081-91.
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