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Chemical Structure : Glutor
Catalog No.: PC-73034Not For Human Use, Lab Use Only.
Glutor (Glucose uptake inhibitor Glutor) is a novel highly potent glucose uptake inhibitor (IC50=10.8 nM) that selectively targets glucose transporters GLUT-1, -2, and -3.
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Glutor (Glucose uptake inhibitor Glutor) is a novel highly potent glucose uptake inhibitor (IC50=10.8 nM) that selectively targets glucose transporters GLUT-1, -2, and -3.
Glutor reduced the uptake of 2-DG with similar potency in different cancer cell lines such as HCT116 (IC50 =10.8 nM), UM-UC-3 (IC50=8.3 nM), UO31 (IC50=3.6 nM), and MIA PaCa-2 (IC50=1.1 nM).
Glutor did not interfere with cellular hexokinase activity and potently reduced glycolytic flux in HCT116 cells.
Glutor induced upregulation of GLUT-1 and -3 in cancer cells, inhibited glycolysis and efficiently suppresseed the growth of various cancer cell lines.
Glutor potently and synergistically inhibited colon cancer cell growth combined with glutaminase inhibitor CB-839.
| M.Wt | 536.636 | |
| Formula | C31H32N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Reckzeh ES, et al. Cell Chem Biol. 2019 Sep 19;26(9):1214-1228.e25.
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