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Chemical Structure : H-PGDS inhibitor 8
CAS No.: 1033836-12-2
Catalog No.: PC-49636Not For Human Use, Lab Use Only.
H-PGDS inhibitor 8 is a potent, selective and orally active hematopoietic prostaglandin D synthase (HPGDS) inhibitor with enzyme IC50 of 0.6 nM, and cell IC50 of 32 nM.
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| 50 mg | $428 | In stock | |
| 100 mg | $728 | In stock | |
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H-PGDS inhibitor 8 is a potent, selective and orally active hematopoietic prostaglandin D synthase (HPGDS) inhibitor with enzyme IC50 of 0.6 nM, and cell IC50 of 32 nM.
H-PGDS inhibitor 8 exhibitd equal potency against purified HPGDS from human, rat, dog, and sheep (IC50, 0.5−2.3 nM).
H-PGDS inhibitor 8 does not inhibit human L-PGDS, mPGES, COX-1, COX-2, or 5 LOX (IC50 values > 10000 nM).
Oral administration of H-PGDS inhibitor 8 (10 mpk) blocked PGD2 production in the rat spleen.
H-PGDS inhibitor 8 (1 mg/mL) completely prevented the LAR (maximum was 86% inhibition of LAR) and blocked the AHR (no change in post antigen PC400) in a model of antigen-induced airway response in allergic sheep.
| M.Wt | 381.37 | |
| Formula | C19H19F4N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-(3-fluorophenyl)-N-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)nicotinamide |
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1. Chris P Carron, et al. ACS Med Chem Lett. 2010 Feb 2;1(2):59-63.
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