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Chemical Structure : HIF2α-IN-2
Catalog No.: PC-62199Not For Human Use, Lab Use Only.
HIF2α-IN-2 is a potent, selective, allosteric inhibitor of HIF-2α PAS-B domain with Kd of 81 nM, shows high selectivity and does not affect HIF-1 function.
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HIF2α-IN-2 is a potent, selective, allosteric inhibitor of HIF-2α PAS-B domain with Kd of 81 nM, shows high selectivity and does not affect HIF-1 function; antagonizes HIF-2 heterodimerization and DNA-binding activity in vitro and in cultured cells, reducing HIF-2 target gene expression.
| M.Wt | 308.653 | |
| Formula | C12H6ClFN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Scheuermann TH, et al. Nat Chem Biol. 2013 Apr;9(4):271-6.
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